Why the study?
Does the I4895T mutation in RyR1 induce fiber-type specific alterations in skeletal muscle that mimic premature aging in mice?
Does the I4895T mutation in RyR1 induce fiber-type specific alterations in skeletal muscle that mimic premature aging in mice?
The I4895T mutation in RyR1 induces fiber-type specific structural and functional alterations in skeletal muscle that mimic premature aging, consistent with reduced calcium release.
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May model RyR1-driven premature muscle aging in mice; hypothesis-generating for human sarcopenia or myopathies, needs validation.
Boncompagni et al. (2010) studied this question.
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