Population
Cultured skeletal myotubes derived from normal and "RyR1-knockout" (dyspedic) mice
Comparison
RyR1 knockout (dyspedic myotubes) vs Normal myotubes
Design
Preclinical
Authors
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Does not inform clinical channelopathy management; extends evidence for RyR1 allosteric modulation of L-channels in skeletal muscle.
RyR1 acts as an important allosteric modulator of the skeletal L-channel, influencing its expression level, activation kinetics, and conductance.
Ávila et al. (2000) studied this question.
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