January 16, 2010Journal of Molecular and Cellular CardiologyOpen Access

Involvement of NADPH oxidase in age-associated cardiac remodeling

View Full Paper

Ask AI

Bookmark

Population

Male Fisher 344 cross Brown Norway rats aged 2 months, 8 months or 30 months

Comparison

Chronic treatment with angiotensin II for 28 days vs Untreated rats of different ages

Design

Preclinical

Follow-up

28 days

Authors

MWMingyi WangChinese PLA General Hospital JZJing ZhangChangchun University of Science and Technology SWSimon WalkerUniversity of Jyväskylä

Discussion

Member takes

Overview

Hypothesis-generating in aged rats; leaves open whether RAAS-Nox2 drives human cardiac aging and warrants clinical trials.

Structured PICO

Population

Male Fisher 344 cross Brown Norway rats aged 2 months (young rats), 8 months (young adult rats) or 30 months (old rats)

Intervention

Chronic treatment with angiotensin II for 28 days (in 8-month-old rats)

Comparator

Untreated rats of different ages (2, 8, and 30 months)

Outcome

Cardiac remodeling parameters including blood pressure, cardiomyocyte area, coronary artery remodeling, cardiac fibrosis, and myocardial NADPH oxidase activitysurrogate

Increased RAAS activation may drive age-related cardiac remodeling through the activation of Nox2 NADPH oxidase and subsequent increases in MMP activation, fibrosis, and cardiomyocyte hypertrophy.

Cite This Study

Wang et al. (2010) studied this question.

synapsesocial.com/papers/6a760f3df1e99ff85ab23260 https://doi.org/10.1016/j.yjmcc.2010.01.006

View Full Paper

Ask AI

Bookmark

January 16, 2010Journal of Molecular and Cellular CardiologyOpen Access

Involvement of NADPH oxidase in age-associated cardiac remodeling

View Full Paper

Ask AI

Bookmark

Population

Male Fisher 344 cross Brown Norway rats aged 2 months, 8 months or 30 months

Comparison

Chronic treatment with angiotensin II for 28 days vs Untreated rats of different ages

Design

Preclinical

Follow-up

28 days

Authors

MWMingyi WangChinese PLA General Hospital JZJing ZhangChangchun University of Science and Technology SWSimon WalkerUniversity of Jyväskylä

Discussion

Member takes

Overview

Hypothesis-generating in aged rats; leaves open whether RAAS-Nox2 drives human cardiac aging and warrants clinical trials.

Structured PICO

Population

Male Fisher 344 cross Brown Norway rats aged 2 months (young rats), 8 months (young adult rats) or 30 months (old rats)

Intervention

Chronic treatment with angiotensin II for 28 days (in 8-month-old rats)

Comparator

Untreated rats of different ages (2, 8, and 30 months)

Outcome

Cardiac remodeling parameters including blood pressure, cardiomyocyte area, coronary artery remodeling, cardiac fibrosis, and myocardial NADPH oxidase activitysurrogate

Increased RAAS activation may drive age-related cardiac remodeling through the activation of Nox2 NADPH oxidase and subsequent increases in MMP activation, fibrosis, and cardiomyocyte hypertrophy.

Cite This Study

Wang et al. (2010) studied this question.

synapsesocial.com/papers/6a760f3df1e99ff85ab23260 https://doi.org/10.1016/j.yjmcc.2010.01.006

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark