A method has been developed for demonstrating atypical serum cholinesterase by means of the self-indicating substrate, o-nitrophenylbutyrate and the inhibitor succinyldicholine. The procedure was tested for atypical cholinesterase with 76 individuals, including 5 otherwise proven homozygotes and their immediate families. In all cases, it was possible to distinguish clearly those individuals homozygous for the usual and atypical cholinesterase as well as heterozygotes.
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McComb et al. (1965) studied this question.
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