Extracellular and Cytoplasmic Domains of Endoglin Interact with the Transforming Growth Factor-β Receptors I and II

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Population

Molecular models studying endoglin and transforming growth factor-beta (TGF-beta) receptors I and II

Design

Preclinical

Authors

Discussion

Endoglin domain interactions with TGF-beta receptors are hypothesis-generating; extends mechanistic insights but leaves open clinical translation.

Population

Molecular models studying endoglin and transforming growth factor-beta (TGF-beta) receptors I and II

Intervention

Expression of full-length and truncated endoglin constructs

Outcome

Interaction between endoglin and TbetaRI/TbetaRII, phosphorylation states, and TGF-beta signaling modulationsurrogate

Endoglin modulates TGF-beta responses by interacting with signaling receptors through specific extracellular and cytoplasmic domains.

Guerrero-Esteo et al. (2002) studied this question.

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Endoglin domain interactions with TGF-beta receptors are hypothesis-generating; extends mechanistic insights but leaves open clinical translation.