What question did this study set out to answer?

To evaluate and compare the in vitro antifungal activity of voriconazole and itraconazole against clinical isolates of Cryptococcus neoformans with differing fluconazole susceptibilities.

February 1, 1998Antimicrobial Agents and ChemotherapyOpen Access

In Vitro Comparative Efficacy of Voriconazole and Itraconazole against Fluconazole-Susceptible and -Resistant Cryptococcus neoformans Isolates

View Full Paper

Ask AI

Bookmark

Authors

MNM. Hong NguyenStanford Medicine CYChristine YuSt. Jude Children's Research Hospital

Discussion

Member takes

Implication

In vitro study demonstrates strong efficacy of voriconazole and itraconazole against drug-resistant Cryptococcus neoformans, highlighting viable alternative therapies for fungal infections.

Key Points

To evaluate and compare the in vitro antifungal activity of voriconazole and itraconazole against clinical isolates of Cryptococcus neoformans with differing fluconazole susceptibilities.
Conducted in vitro susceptibility testing on 50 clinical isolates of Cryptococcus neoformans categorized as fluconazole-susceptible, dose-dependent, or fluconazole-resistant.
Measured and compared the minimum inhibitory concentrations (MICs) of voriconazole and itraconazole across each susceptibility category.
Voriconazole showed higher potency than itraconazole against fluconazole-susceptible isolates.
Both voriconazole and itraconazole displayed equivalent potency against fluconazole-susceptible dose-dependent and fluconazole-resistant isolates, with MICs ranging from 1 to 2 µg/ml in resistant strains.

Cite This Study

Nguyen et al. (1998) studied this question.

synapsesocial.com/papers/6a7614d967b8a7e548707adc https://doi.org/10.1128/aac.42.2.471

View Full Paper

Ask AI

Bookmark

Implication

In vitro study demonstrates strong efficacy of voriconazole and itraconazole against drug-resistant Cryptococcus neoformans, highlighting viable alternative therapies for fungal infections.

In Vitro Comparative Efficacy of Voriconazole and Itraconazole against Fluconazole-Susceptible and -Resistant Cryptococcus neoformans Isolates

Discussion

Member takes

Implication

Key Points

Cite This Study

In Vitro Comparative Efficacy of Voriconazole and Itraconazole against Fluconazole-Susceptible and -Resistant Cryptococcus neoformans Isolates

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider