Why the study?
Endothelin-1 acts as a vasoconstrictor and inhibits adiponectin expression in obesity, but the relationship between the Lys198Asn polymorphism of the endothelin-1 gene and plasma endothelin-1 levels in an obese Javanese population needed investigation.
Does the Lys198Asn polymorphism of the endothelin-1 gene increase endothelin-1 plasma levels and obesity risk in a Javanese population?
Does the Lys198Asn polymorphism of the endothelin-1 gene increase endothelin-1 plasma levels and obesity risk in a Javanese population?
The Lys198Asn polymorphism (TT genotype) of the endothelin-1 gene is associated with increased endothelin-1 plasma levels and a higher risk of obesity in a Javanese population.
Answers are grounded in this paper and cite their sources.
Associated with higher ET-1 levels and obesity risk in small Javanese cohort; leaves open causal or clinical relevance pending replication.
Background: Endothelin-1 plays a role as a vasoconstrictor and also inhibits the expression of adiponectin in obesity. The Lys198Asn polymorphism of the endothelin-1 gene will increase the level of endothelin-1 plasma and increase the risk factor of obesity. Objective: In this study, we investigated the relationship between Lys198Asn polymorphism of endothelin-1 gene and endothelin-1 plasma level among individuals with obesity in Javanese population. Method: This study was conducted on 61 obese subjects and 65 control subjects. All subjects were measured for anthropometrics and endothelin-1 plasma level by ELISA (Enzyme-linked Immune Sorbent Assay). The polymorphism of Lys198Asn of ET-1 (Endothelin-1) was screened by using PCRRFLP (Polymerase Chain Reaction- Restriction Fragment Length Polymorphism). Results: TT genotype was a risk factor of obesity (OR 5.344 CI=95% 1.77-16.16) compared with GG genotype. Levels of endothelin-1 plasma were higher in obese subjects than that of control subjects (p=0.013), with TT genotype having the highest endothelin-1 plasma level (p<0.001). Conclusion: The Lys198Asn polymorphism of endothelin-1 gene plays a role in increasing endothelin-1 plasma levels and is risk factors of obesity. Bangladesh Journal of Medical Science Vol.18(1) 2019 p.46-49
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Karita et al. (2018) studied this question.
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