Why the study?
Does the ET-1 K198N (G/T) polymorphism interact with BMI to increase the risk of hypertension in Japanese populations?
Population
2 large Japanese populations
Comparison
ET-1 K198N (G/T) polymorphism (T allele carriers) vs GG homozygotes
Design
Cohort
Authors
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Supports ET-1 K198N-BMI interaction in Japanese hypertension risk; hypothesis-generating, requires replication before clinical use.
Does the ET-1 K198N (G/T) polymorphism interact with BMI to increase the risk of hypertension in Japanese populations?
The ET-1 K198N T allele interacts with BMI to increase hypertension risk, suggesting T allele carriers may particularly benefit from weight reduction.
Jin et al. (2003) studied this question.
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