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Transient cerebral ischemia induces hsp72 expression in distinct cortical and striatal cell populations.
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Transient global and transient focal ischemia induced the 72 kDa heat shock protein (hsp72) in neurons in cortex, striatum, and other regions known to be injured during transient ischemia. A novel finding was the induction of hsp72 in islands (cylinders in three dimensions) of cells composed of astrocytes around the perimeter and neurons in the interior. Since histology showed pale staining in these regions, it is proposed that these islands represent areas of focal infarction in the distribution of small cortical and lenticulostriate arteries. Although the factors responsible for hsp72 induction during ischemia and infarction are unknown, these results suggest differences in mechanisms of hsp72 induction in astrocytes compared to neurons.
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Sharp et al. (1991) studied Transient global and focal cerebral ischemia and infarction. Transient global and transient focal ischemia was evaluated on Induction of 72 kDa heat shock protein (hsp72) in cortical and striatal astrocytes and neurons. Transient global and focal ischemia induced 72 kDa heat shock protein (hsp72) in cortical and striatal neurons and in cylindrical islands of peripheral astrocytes and interior neurons.
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