Challenges in the Development of Exoskeletons for People with Disabilities

The development of exoskeletons aimed at enhancing the mobility and autonomy of people with disabilities marks a significant advance toward social and occupational inclusion, fostering greater independence and improved quality of life. However, their implementation poses multidisciplinary challenges, including technical issues, usability, cost, and user acceptance. This article synthesizes the main challenges, recent advancements, and future perspectives identified in scientific literature through a systematic review conducted under the PRISMA® methodology. Forty-three high-impact publications indexed in SCOPUS, Web of Science, ScienceDirect, Taylor & Francis, IEEE Xplore, and PubMed were analyzed, showing an almost perfect inter-rater agreement (Cohen’s Kappa = 0.8390). The findings underscore the need to optimize control systems, reduce costs, and improve device adaptability. Artificial intelligence emerges as a key enabler to overcome these limitations, offering more efficient, affordable, and personalized solutions. This work provides an up-to-date overview of the field and outlines future directions for exoskeleton research and development, highlighting their transformative potential in the lives of people with disabilities.