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High-renin profile was associated with higher MI risk in treated hypertension; leaves open whether renin-guided therapy improves outcomes.
HYPERTENSION is a major risk factor for cardiovascular disease. In its pathophysiologic features and clinical sequelae, hypertension is recognized to be a heterogeneous disorder. Although some patients are at increased risk for coronary heart disease, others seem not to be. In the past several years, much effort has been made to identify the factors that increase the risk of coronary heart disease in subjects with hypertension and to understand the pathophysiologic features of the ischemic events in such cases. Accordingly, epidemiologic studies have documented the importance of factors such as hypercholesterolemia, glucose intolerance, cardiac hypertrophy, and cigarette smoking to the . . .
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Victor J. Dzau (1991) studied this question.
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