Why the study?
Does MAO-A upregulation cause oxidative mitochondrial damage and chronic left ventricular dysfunction in mice?
Population
Transgenic mice with cardiac-specific MAO-A overexpression under the control of the α-myosin heavy chain…
Comparison
Cardiac-specific MAO-A overexpression; chronic… vs Non-transgenic littermates; untreated Tg mice…
Design
Preclinical
Follow-up
up to 9 months
Authors
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MAO-A inhibition rescues function in transgenic mice; leaves open whether targeting MAO-A alters human HF progression.
Does MAO-A upregulation cause oxidative mitochondrial damage and chronic left ventricular dysfunction in mice?
Cardiac-specific upregulation of MAO-A causes oxidative mitochondrial damage, p53-dependent repression of PGC-1α, cardiomyocyte necrosis, and chronic ventricular dysfunction in mice.
Villeneuve et al. (2012) studied this question.
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