Why the study?
Melanoma induces cardiac atrophy and impairs cardiac function in vivo, but its effect on intrinsic heart function and potential attenuation by short-term voluntary exercise remained uninvestigated.
Does short-term voluntary wheel-running exercise improve intrinsic heart function in noncachectic mice with subcutaneous B16 melanoma?
Does short-term voluntary wheel-running exercise improve intrinsic heart function in noncachectic mice with subcutaneous B16 melanoma?
Subcutaneous melanoma impairs intrinsic cardiac function in mice, which is not restored by short-term voluntary exercise.
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Melanoma impairs intrinsic cardiac function in noncachectic mice; leaves open exercise effects and human relevance.
Melanoma has been shown to induce cardiac atrophy and impair cardiac function in vivo, however, it has not been investigated how melanoma affects the intrinsic heart function. Here, we showed that subcutaneous melanoma can impair intrinsic heart function in noncachectic mice, decreasing the heart's pressure production and relaxation. In addition, we investigated whether short-term voluntary wheel-running exercise could attenuate the impairment of intrinsic cardiac function. However, our results do not seem to support this hypothesis.
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Uurasmaa et al. (2022) studied this question.
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