TGBp2 of Bamboo mosaic virus binds viral RNA non-specifically, which may facilitate intracellular viral RNA delivery.
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Non-specific TGBp2-RNA binding persists despite residue mutations; leaves open mechanistic details of viral RNA delivery in plant cells.
The triple-gene-block protein 2 (TGBp2) of Bamboo mosaic virus (BaMV) is a transmembrane protein which was proposed to be involved in viral RNA binding during virus transport. Here, we report on the RNA-binding properties of TGBp2. Using tyrosine fluorescence spectroscopy and UV-crosslinking assays, the TGBp2 solubilized with Triton X-100 was found to interact with viral RNA in a non-specific manner. These results raise the possibility that TGBp2 facilitates intracellular delivery of viral RNA through non-specific protein-RNA interaction.
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Hsu et al. (2009) studied this question.
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