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June 1, 2003AJP Regulatory Integrative and Comparative Physiology

Role of renal NO production in the regulation of medullary blood flow

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Population

Preclinical models including Dahl salt-sensitive (S) rats

Design

Review

Authors

ACAllen W. CowleyPreventive CardiologyTMTakefumi MoriVascular MedicineDMDavid L. MattsonAugusta University

Discussion

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Implication

May guide mechanistic hypertension research on renal NO pathways; hypothesis-generating without clinical practice implications.

Structured PICO

P
Population
Preclinical models including Dahl salt-sensitive (S) rats
I
Intervention
Modulation of renal medullary nitric oxide (NO) production
O
Outcome
Regulation of medullary blood flow, sodium excretion, and blood pressure

Nitric oxide production in the renal medulla plays a critical role in sodium and water homeostasis and the long-term control of arterial pressure.

Cite This Study

Cowley et al. (2003) studied this question.

synapsesocial.com/papers/6a761f2274b63c188eb21ca0https://doi.org/10.1152/ajpregu.00701.2002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nitric oxide synthase responsible for l ‐arginine‐induced relaxation of rat aortic rings in vitro may be an inducible type1992 · 32 citations
  2. 2Modulation of angiotensin II-induced vasoconstriction by endothelium-derived relaxing factor in the isolated microperfused rabbit afferent arteriole.1991 · 215 citations
  3. 3NITRIC OXIDE, THE KIDNEY AND HYPERTENSION1997 · 30 citations
  4. 4Role of abnormal nitric oxide systems in salt-sensitive hypertension2001 · 61 citations
  5. 5Quantification of nitric oxide synthase activity in microdissected segments of the rat kidney1999 · 181 citations