Population
In vitro platelet assays and in vivo cynomolgus monkey model of cyclic flow reductions in the femoral artery
Design
Preclinical
Authors
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Hypothesis-generating for selective Gαq/11 inhibition in thrombosis; human trials needed before any clinical consideration.
YM-254890 is a specific Galpha(q/11) inhibitor that effectively inhibits platelet aggregation and thrombus formation in preclinical models without prolonging bleeding time.
Uemura et al. (2006) studied this question.
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