Why the study?
ESRD patients receiving hemodialysis were excluded from landmark trials evaluating direct-acting oral anticoagulants in AF.
Do DOACs reduce bleeding compared to warfarin in patients with atrial fibrillation on chronic hemodialysis?
Comparison
DOACs vs warfarin
Design
Retrospective observational study
Authors
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Bleeding risk with DOACs vs warfarin in HD patients with AF remains uncertain; leaves open optimal choice pending randomized trials.
Do DOACs reduce bleeding compared to warfarin in patients with atrial fibrillation on chronic hemodialysis?
In patients with atrial fibrillation on chronic hemodialysis, DOACs were associated with a lower incidence of bleeding compared to warfarin, though inappropriate DOAC dosing remains a safety concern.
Davis et al. (2020) studied this question.
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