A different background of arrhythmia in siblings with a positive family history of sudden death at young age

Figures

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  Figure 1. The pedigree of the family with DES c.735 + 3A>G mutation

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  Figure 2. 12‐lead standard electrocardiogram in the proband. Sinus rhythm 63/min, PR 130ms, nonspecific intraventricular conduction delay, QRS 119 ms, QTc 401 ms

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  Figure 3. A strip of 12‐lead Holter ECG monitoring revealing nonsustained ventricular tachycardia of RBBB morphology in the proband

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  Figure 4. Cardiac magnetic resonance, 4‐chamber view revealing normal heart morphology

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  Figure 5. A standard 12‐lead ECG in the elder sister revealing sinus rhythm with frequent ventricular ectopy, also paired beats of LBBB morphology

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  Figure 6. Chromatogram from direct sequencing by the Sanger method showing DES: NM_001927.3: c.735 + 3A>G variant found by TruSight One panel in the proband and in none of the examined relatives. IGV view of the mutation below chromatogram