Why the study?
Does overexpression of miR-150 reduce myocardial injury and improve cardiac function in a mouse model of acute myocardial infarction?
Population
Mouse model of acute myocardial infarction (AMI), human subjects with AMI, and in vitro monocyte models
Comparison
Overexpression of miR-150 vs Blockade of miR-150, or wild-type mice…
Design
Preclinical
Authors
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miR-150 overexpression attenuates murine AMI injury; leaves open human translation and prospective trials.
Does overexpression of miR-150 reduce myocardial injury and improve cardiac function in a mouse model of acute myocardial infarction?
miR-150 protects against AMI-induced injury by inhibiting CXCR4-mediated monocyte migration and proinflammatory cytokine production.
Liu et al. (2014) studied this question.
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