What question did this study set out to answer?

To establish the therapeutic rationale and technical feasibility of metronomic photodynamic therapy (mPDT) using continuous, low-dose photosensitizer and light delivery to selectively eradicate malignant brain tumors.

January 1, 2004Photochemistry and Photobiology

Metronomic Photodynamic Therapy as a New Paradigm for Photodynamic Therapy: Rationale and Preclinical Evaluation of Technical Feasibility for Treating Malignant Brain Tumors¶

View Full Paper

Ask AI

Bookmark

Authors

SBStuart K. BislandOntario Institute for Cancer Research LLLothar LilgeUniversity Health Network ALAnnie LinSt. Michael's Hospital

Discussion

Member takes

Implication

Preclinical study reveals continuous low-dose photodynamic therapy selectively induces tumor apoptosis in brain tumor models, suggesting a feasible strategy to treat invasive gliomas safely.

Key Points

To establish the therapeutic rationale and technical feasibility of metronomic photodynamic therapy (mPDT) using continuous, low-dose photosensitizer and light delivery to selectively eradicate malignant brain tumors.
Assessed in vitro apoptosis induction comparing continuous, low-dose metronomic photodynamic therapy against acute high-dose regimens.
Administered 5-aminolevulinic acid (ALA) in drinking water at up to 10 times therapeutic doses for up to 10 days in 9L gliosarcoma rat models to assess protoporphyrin IX (PpIX) tumor-to-brain accumulation via ex vivo spectrofluorimetry.
Engineered prototype chronic light-delivery devices, evaluating fiber-coupled laser diodes and LEDs in rats and directly implanted LEDs in rabbits to allow unencumbered mobility during extended illumination.
In vitro ALA-mPDT stimulated a higher incidence of apoptotic, TUNEL-positive tumor cells compared to acute high-dose ALA photodynamic therapy.
Extended oral administration of ALA achieved a 3- to 4-fold increase in the tumor-to-brain PpIX concentration ratio with no detectable systemic toxicity.
Chronic low-dose light delivery produced extensive selective apoptosis along tumor margins and microinvasive clusters without causing apoptosis or necrosis in normal brain tissue.

Cite This Study

Bisland et al. (2004) studied this question.

synapsesocial.com/papers/6a762889f1e99ff85ab23f14 https://doi.org/10.1562/2004-03-05-ra-100.1

View Full Paper

Ask AI

Bookmark

Implication

Preclinical study reveals continuous low-dose photodynamic therapy selectively induces tumor apoptosis in brain tumor models, suggesting a feasible strategy to treat invasive gliomas safely.

Metronomic Photodynamic Therapy as a New Paradigm for Photodynamic Therapy: Rationale and Preclinical Evaluation of Technical Feasibility for Treating Malignant Brain Tumors¶

Discussion

Member takes

Implication

Key Points

Cite This Study

Metronomic Photodynamic Therapy as a New Paradigm for Photodynamic Therapy: Rationale and Preclinical Evaluation of Technical Feasibility for Treating Malignant Brain Tumors¶

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider