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May 1, 1988Biochemistry

Molecular basis for sequence-specific DNA alkylation by CC-1065

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Authors

LHLaurence H. HurleyUniversity of ArizonaCLChong Soon LeeUniversity of Southern CaliforniaJMJ. Patrick McGovrenPfizer (United States)

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Hurley et al. (1988) studied this question.

synapsesocial.com/papers/6a7628bad65efbf82c8c5948https://doi.org/10.1021/bi00410a054
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Some Pertinent Aspects of Mechanism as Determined with Small Molecules1976 · 100 citations
  2. 2Sequence-specific cleavage of double-helical DNA. N-Bromoacetyldistamycin1985 · 31 citations
  3. 3Stereoelectronic factors influencing the biological activity and DNA interaction of synthetic antitumor agents modeled on CC-10651988 · 129 citations
  4. 4Methidiumpropyl-EDTA-Fe(II) and DNase I footprinting report different small molecule binding site sizes on DNA1983 · 175 citations
  5. 5CC-1065 (NSC-298223), a new antitumor antibiotic. Production, in vitro biological activity, microbiological assays and taxonomy of the producing microorganism.1978 · 274 citations