Why the study?
Does sitagliptin augment the renovascular effects of angiotensin II in kidneys from spontaneously hypertensive rats?
Does sitagliptin augment the renovascular effects of angiotensin II in kidneys from spontaneously hypertensive rats?
Sitagliptin augments sympathetic enhancement of renovascular responses to angiotensin II in genetically hypertensive rats by preventing the metabolism of neuropeptide Y(1-36), suggesting potential renal implications for DPP-4 inhibitors in hypertensive diabetic patients.
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May warrant caution with DPP-4 inhibitors in hypertension; leaves open human translation of rat renovascular effects.
Jackson et al. (2008) studied this question.
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