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February 17, 2004The Journal of PhysiologyOpen Access

Essential role of troponin I in the positive inotropic response to isoprenaline in mouse hearts contracting auxotonically

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Population

Isolated hearts and isolated cardiomyocytes from transgenic mice with cardiac-specific expression of slow…

Comparison

Isoprenaline (10 nm) vs Wild-type littermate controls

Design

Preclinical

Authors

JLJoanne LaylandRoyal Adelaide HospitalDGDavid GrieveHeart Failure & TransplantACAlison CaveEuropean Medicines Agency

Discussion

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Implication

Suggests troponin I mediates load-dependent beta-adrenergic inotropy in mice; hypothesis-generating for human translation.

Structured PICO

P
Population
Isolated hearts and isolated cardiomyocytes from transgenic mice with cardiac-specific expression of slow skeletal TnI (ssTnI) and matched wild-type littermate controls
I
Intervention
Isoprenaline (10 nm)
C
Comparator
Wild-type littermate controls
O
Outcome
Contractile response including lusitropic and positive inotropic effects (ejection-phase indices, left ventricular end-systolic volume, stroke work, end-systolic pressure-volume relation, intracellular Ca2+ transients)surrogate

Cardiac troponin I plays a pivotal role in the positive inotropic response of the murine heart to beta-adrenergic stimulation, an effect highly dependent on loading conditions.

Cite This Study

Layland et al. (2004) studied this question.

synapsesocial.com/papers/6a762c347d7eb453cc708dc4https://doi.org/10.1113/jphysiol.2004.061176
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Phosphorylation of Troponin I Controls Cardiac Twitch Dynamics2002 · 123 citations
  2. 2Phosphorylation of Troponin I by Protein Kinase A Accelerates Relaxation and Crossbridge Cycle Kinetics in Mouse Ventricular Muscle2001 · 340 citations
  3. 3Phosphorylation of phospholamban and troponin I in β-adrenergic-induced acceleration of cardiac relaxation2000 · 239 citations
  4. 4Expression of Slow Skeletal Troponin I in Hearts of Phospholamban Knockout Mice Alters the Relaxant Effect of β-Adrenergic Stimulation2002 · 54 citations
  5. 5Myofilament‐based relaxant effect of isoprenaline revealed during work‐loop contractions in rat cardiac trabeculae2002 · 19 citations