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April 9, 2013Hepatitis MonthlyOpen Access

Probiotics as a Novel Treatment for Non-Alcoholic Fatty Liver Disease; A Systematic Review on the Current Evidences

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Why the study?

Do probiotics improve disease markers in patients and animal models with non-alcoholic fatty liver disease?

Population

Patients and animal models with non-alcoholic fatty liver disease or non-alcoholic steatohepatitis

Design

Systematic_review

Authors

RKRoya KelishadiPreventive CardiologySFSanam FarajianIsfahan University of Medical SciencesMMMaryam MirlohiIsfahan University of Medical Sciences

Discussion

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Implication

Probiotics may offer adjunctive NAFLD benefit; leaves open confirmation of clinical outcomes in large RCTs.

Structured PICO

Do probiotics improve disease markers in patients and animal models with non-alcoholic fatty liver disease?

P
Population
Patients and animal models with non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH)
I
Intervention
Probiotics (various strains including VSL#3, Lactobacillus, Bifidobacterium, and Streptococcus)
O
Outcome
Improvement in NAFLD markers including liver enzymes, lipid peroxidation, steatosis, and inflammatory cytokinessurrogate

Probiotics may offer a novel therapeutic approach for NAFLD by modulating gut microbiota and reducing inflammation and oxidative stress, though larger, long-term trials are needed to substantiate these findings.

Limitations

  • limited experience in this field
  • small sample sizes in available trials
  • short-term follow up in available trials

Cite This Study

Kelishadi et al. (2013) studied this question.

synapsesocial.com/papers/6a762cfecd662f67b2fbdf55https://doi.org/10.5812/hepatmon.7233
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Epidemiology of Nonalcoholic Fatty Liver Disease: A Global Perspective2008 · 738 citations
  2. 2Nonalcoholic fatty liver in Asia: Firmly entrenched and rapidly gaining ground2011 · 172 citations
  3. 3Prevalence of Hepatic Steatosis in An Urban Population in the United States: Impact of Ethnicity2004 · 3,695 citations
  4. 4Cardiovascular Risk Factors, Nonalcoholic Fatty Liver Disease, and Carotid Artery Intima-Media Thickness in an Adolescent Population in Southern Italy2010 · 83 citations
  5. 5Patients, gastroenterologists, and the World Wide Web1998 · 17 citations