Case-control study demonstrates distinct ventricular dilation and aqueductal flow voids in normal pressure hydrocephalus, highlighting specific MRI markers for differential diagnosis.
Background: Differentiation of NPH from other neurodegenerative diseases is challenging due to overlapping clinical & imaging features. This study aims to demonstrate various conventional MRI ndings in clinically suspected patients of NPH. The study group comprised 36 patients and 10 asymptomatic age-matched controls. They were assessed on MRI for Evans'Methods: index, callosal angle, Sylvian ssure width, third ventricle diameter, temporal horn of lateral ventricle diameter, deep white matter hyperintensities, & aqueductal ow void. In controls & cases respectively, Evans' index was 0.26 ± 0.02 & 0.34 ± 0.04, callosal angleResults: was 104.5 ± 5.5° & 84.0 ± 8.7°, Sylvian ssure width was 3.2 ± 0.9 mm & 6.5 ± 1.4 mm, third ventricle diameter was 5.8 ± 1.3 mm & 12.7 ± 2.6 mm, & temporal horn diameter was 3.9 ± 0.9 mm & 7.4 ± 2.3 mm. Percentages of controls & cases with various grades of DWMH were similar. Aqueductal ow void was seen in 94.4% of cases & none of the controls. NPH patients have higher Evans' index, smaller callosalConclusion: angle, wide Sylvian ssures, dilated third ventricle & temporal horns compared to controls. CSF ow void is exclusively seen in cases. There is no difference in DWMH between cases and controls.
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Shaheen et al. (2022) studied this question.
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