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The incidence of hyperfibrinogenemia was studied in 1961 patients with different malignancies. Hyperfibrinogenemia was found to be associated with rapidly growing tumors. On the one hand, carcinomas, sarcomas, and Hodgkin's disease presented hyperfibrinogenemia very frequently. On the other hand, chronic leukemias and lymphosarcomas seldom presented hyperfibrinogenemia. This study confirms that hyperfibrinogenemia and hypercoagulability might play a role in the growth of tumors and indicates the tumors more suitable for future prospective studies.
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Brugarolas et al. (1973) studied this question.
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