Why the study?
Does a genetic scoring approach identify associations between renin-angiotensin and kinin-bradykinin system genes and permanent arterial hypertension in children?
Does a genetic scoring approach identify associations between renin-angiotensin and kinin-bradykinin system genes and permanent arterial hypertension in children?
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A novel genetic scoring approach suggests that renin-angiotensin and kinin-bradykinin system genes play a significant role in permanent arterial hypertension in girls.
A new approach, based on scoring, was proposed for a more objective estimation of the contribution of several genetic variants to a multifactorial disease. Two variants of the approach—genotype scoring and unfavorable factor scoring—were tested by analyzing the polymorphisms of REN (I9–83G>A), AGT (M235T), ACE (I/D), AGTR1 (1166A>C), ATGR2 (3123C>A), and BKR2 (−58T>C and I/D) in children with arterial hypertension (AH). Each of the two variants reported that the genes of the renin-angiotensin and kinin-brady-kinin systems play an important role in permanent AH in girls.
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Glotov et al. (2007) studied this question.
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