Why the study?
What are the practical recommendations for patient selection, timing of initiation, and duration of ACE inhibitor therapy in patients with acute myocardial infarction?
What are the practical recommendations for patient selection, timing of initiation, and duration of ACE inhibitor therapy in patients with acute myocardial infarction?
This review provides practical clinical recommendations on the initiation, timing, and duration of ACE inhibitor therapy in patients following an acute myocardial infarction.
May guide post-AMI ACE inhibitor decisions; leaves open optimal selection, timing, and duration.
Numerous large, double-blind, randomized trials have demonstrated that, overall, angiotensin converting enzyme (ACE) inhibition improves survival of patients after acute myocardial infarction (AMI). However, several practical issues concerning ACE inhibition in the presence of AMI have not yet been answered. These include whether ACE inhibition should be initiated in all patients with AMI, how soon ACE inhibition should be attempted in relation to onset of pain and possibly thrombolysis, and, lastly, how long ACE inhibition should be maintained after the acute event. Each of these issues is addressed, and recommendations are made on the basis of the results from recent randomized trials in AMI and congestive heart failure.
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Testa et al. (1995) studied this question.
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