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A characteristic infection pattern was observed in nonscarified adult guinea-pigs that had been artificially infected with Candida albicans, and injected with 1 dose of 200 mg/kg of alloxan. Lesions appeared less rapidly in nonscarified animals but within 8–15 days of the induced infection the lesions were maximal and were much more homogeneous than in scarified animals. The guinea-pig is an excellent laboratory model for the study of anticandidal substances.
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Cutsem et al. (1971) studied this question.
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