Why the study?
Does the combined use of beta-blockers and sodium channel blockers worsen the clinical presentation of drug-induced bradycardia compared to beta-blockers alone in elderly patients?
Does the combined use of beta-blockers and sodium channel blockers worsen the clinical presentation of drug-induced bradycardia compared to beta-blockers alone in elderly patients?
The combination of beta-blockers and sodium channel blockers can cause life-threatening bradycardia in the elderly, even months after initiation and without QRS prolongation.
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Alerts clinicians to possible severe bradycardia with beta-blocker plus Na channel blocker combos in elderly; hypothesis-generating, needs prospective confirmation.
Kawabata et al. (2015) studied this question.
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