November 23, 2011PLoS ONEOpen Access

In Vitro Effects of Pirfenidone on Cardiac Fibroblasts: Proliferation, Myofibroblast Differentiation, Migration and Cytokine Secretion

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Population

Cardiac fibroblasts (CFs) isolated from the ventricles of neonatal Sprague-Dawley rats (1-3 days old)

Comparison

Pirfenidone at various concentrations… vs 0 mg/ml pirfenidone (control group)

Design

Preclinical

Follow-up

Up to 72 hours (in vitro)

Authors

QSQiang ShiUniversity of South China XLXiaoyan LiuHebei University of Engineering YBYuanyuan BaiThe Affiliated Yongchuan Hospital of Chongqing Medical University

Discussion

Member takes

Implication

Supports pirfenidone exploration in myocardial fibrosis; hypothesis-generating in vitro data leave clinical translation open.

Structured PICO

Population

Cardiac fibroblasts (CFs) isolated from the ventricles of neonatal Sprague-Dawley rats (1-3 days old)

Intervention

Pirfenidone at various concentrations (0.1, 0.5, 1.0, and 1.5 mg/ml) administered in vitro for 12, 24, 48, or 72 hours

Comparator

0 mg/ml pirfenidone (control group)

Outcome

Cardiac fibroblast proliferation, myofibroblast differentiation (a-SMA expression and collagen contractility), migration, and cytokine secretion (TGF-b1, IL-10, MMP-9, TIMP-1)surrogate

Pirfenidone exerts direct pleiotropic antifibrotic effects on cardiac fibroblasts in vitro, supporting its potential use in treating adverse myocardial remodeling.

Cite This Study

Shi et al. (2011) studied this question.

synapsesocial.com/papers/6a7636db9aebbbed36614d65 https://doi.org/10.1371/journal.pone.0028134

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In Vitro Effects of Pirfenidone on Cardiac Fibroblasts: Proliferation, Myofibroblast Differentiation, Migration and Cytokine Secretion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

In Vitro Effects of Pirfenidone on Cardiac Fibroblasts: Proliferation, Myofibroblast Differentiation, Migration and Cytokine Secretion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider