Why the study?
The persistent effects of COVID-19 on vascular function in otherwise healthy young adults had not been previously investigated.
Does persistent symptomatic COVID-19 infection impair vascular function in young otherwise healthy adults?
Does persistent symptomatic COVID-19 infection impair vascular function in young otherwise healthy adults?
Persistent COVID-19 symptoms in young healthy adults are associated with blunted peripheral vasodilation, but not cerebral vascular dysfunction or central arterial stiffness.
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Persistent symptoms may signal vascular impairment warranting evaluation in young adults post-COVID; hypothesis-generating for long-term risk and interventions.
This study was the first to investigate the persistent effects of COVID-19 on vascular function in otherwise healthy young adults. We demonstrated that peripheral macrovascular and microvascular vasodilation was significantly blunted in young adults still symptomatic from COVID-19 beyond the acute phase (>4 wk from diagnosis), whereas those who become asymptomatic have similar vascular function compared with controls who never had COVID-19. In contrast, cerebral vascular function and central arterial stiffness were unaffected irrespective of COVID-19 symptomology.
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Nandadeva et al. (2021) studied this question.
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