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A detailed proof of hard-scattering factorization is given with the inclusion of heavy quark masses. Although the proof is explicitly given for deep-inelastic scattering, the methods apply more generally. The power-suppressed corrections to the factorization formula are uniformly suppressed by a power of Λ/Q, independently of the size of heavy quark masses, $M,$ relative to $Q.$
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John C. Collins (1998) studied this question.
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