What question did this study set out to answer?

To determine whether adding annual fecal occult blood testing to regular sigmoidoscopy improves compliance, cancer detection, and mortality compared to sigmoidoscopy alone.

August 1, 1993JNCI Journal of the National Cancer Institute

Screening for Colorectal Cancer With Fecal Occult Blood Testing and Sigmoidoscopy

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Authors

SWS. J. WinawerMemorial Sloan Kettering Cancer Center BFBetty J. FlehingerMemorial Hospital of South Bend DSDavid SchottenfeldUniversity of Michigan

Discussion

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Implication

Controlled screening trial demonstrates improved survival and early detection with combined fecal occult blood testing and sigmoidoscopy in adults, indicating clear diagnostic benefits.

Key Points

To determine whether adding annual fecal occult blood testing to regular sigmoidoscopy improves compliance, cancer detection, and mortality compared to sigmoidoscopy alone.
Controlled screening trial of 21,756 adults aged 40 and older enrolled by calendar period between 1975 and 1979 at the Preventive Medicine Institute-Strang Clinic with follow-up through 1984.
Patients were allocated to rigid sigmoidoscopy plus annual fecal occult blood tests (two stool specimens per day for 3 days) or annual sigmoidoscopy alone across two distinct cohorts (Trial I, N=9,277; Trial II, N=12,479).
Positive screening tests prompted referral for diagnostic double-contrast barium enema and colonoscopy.
Adherence to repeat fecal occult blood testing declined to 56% in Trial I and 20% in Trial II.
In Trial II, the survival probability was significantly higher in the combined screening group than in controls (70% vs. 48%, P < .001).
Colorectal cancer mortality in Trial II was lower in the combined screening group than in controls (0.36 vs. 0.63; one-sided P = .053).

Cite This Study

Winawer et al. (1993) studied this question.

synapsesocial.com/papers/6a763ccc59770ea2c0bcb32e https://doi.org/10.1093/jnci/85.16.1311

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August 1, 1993JNCI Journal of the National Cancer Institute

Screening for Colorectal Cancer With Fecal Occult Blood Testing and Sigmoidoscopy

View Full Paper

Ask AI

Bookmark

Authors

SWS. J. WinawerMemorial Sloan Kettering Cancer Center BFBetty J. FlehingerMemorial Hospital of South Bend DSDavid SchottenfeldUniversity of Michigan

Discussion

Member takes

Implication

Controlled screening trial demonstrates improved survival and early detection with combined fecal occult blood testing and sigmoidoscopy in adults, indicating clear diagnostic benefits.

Key Points

To determine whether adding annual fecal occult blood testing to regular sigmoidoscopy improves compliance, cancer detection, and mortality compared to sigmoidoscopy alone.
Controlled screening trial of 21,756 adults aged 40 and older enrolled by calendar period between 1975 and 1979 at the Preventive Medicine Institute-Strang Clinic with follow-up through 1984.
Patients were allocated to rigid sigmoidoscopy plus annual fecal occult blood tests (two stool specimens per day for 3 days) or annual sigmoidoscopy alone across two distinct cohorts (Trial I, N=9,277; Trial II, N=12,479).
Positive screening tests prompted referral for diagnostic double-contrast barium enema and colonoscopy.
Adherence to repeat fecal occult blood testing declined to 56% in Trial I and 20% in Trial II.
In Trial II, the survival probability was significantly higher in the combined screening group than in controls (70% vs. 48%, P < .001).
Colorectal cancer mortality in Trial II was lower in the combined screening group than in controls (0.36 vs. 0.63; one-sided P = .053).

Cite This Study

Winawer et al. (1993) studied this question.

synapsesocial.com/papers/6a763ccc59770ea2c0bcb32e https://doi.org/10.1093/jnci/85.16.1311

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