Why the study?
Does Guinea pig IgG2 anti-idiotypic antibody suppress the expression of the A5A idiotype in adult A/J mice immunized with Group A streptococci?
Population
Adult A/J mice immunized with Group A streptococci
Design
Preclinical
Follow-up
more than 1 year
Authors
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Low-dose aId2 induces prolonged T-cell suppression in mice; leaves open translation to human idiotype regulation or therapy.
Does Guinea pig IgG2 anti-idiotypic antibody suppress the expression of the A5A idiotype in adult A/J mice immunized with Group A streptococci?
Low doses of anti-idiotypic antibody induce a delayed but chronic, transferable suppression of idiotype expression mediated by T cells.
Klaus Eichmann (1975) studied this question.
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