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January 31, 1956American Journal of Physiology-Legacy Content

Pressure-Volume Curves of the Arterial and Venous Systems in Live Dogs

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Population

Live dogs (specifically referencing a 12-kg dog model)

Comparison

Measurement of pressure-volume curves under… vs Static conditions (circulation at a standstill)

Design

Preclinical

Authors

AGArthur C. GuytonEmory UniversityGAGeorge G. ArmstrongGeorge Eliot HospitalPCPatrick L. ChipleyUniversity of Mississippi

Discussion

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Implication

Supports venous dominance as blood reservoir in dogs; leaves open translation to human volume management.

Key Points

  • Determine and compare the pressure-volume relationships and vascular capacitance of the arterial and venous systems in living canines under dynamic and static circulatory states.
  • Measured pressure-volume curves in the arterial and venous vascular beds of live dogs weighing approximately 12 kg.
  • Compared blood volume distribution during normal cardiac pumping against circulatory standstill to calculate vascular capacitance (dV/dP).
  • Normal dynamic heart pumping held approximately 60 cc more blood in the arterial system and 60 cc less in the venous system compared to static standstill conditions.
  • Venous capacitance (dV/dP) averaged 18 to 30 times greater than arterial capacitance across the measured physiological pressure ranges.

Structured PICO

P
Population
Live dogs (specifically referencing a 12-kg dog model)
I
Intervention
Measurement of pressure-volume curves under normal dynamic conditions (heart pumping normally)
C
Comparator
Static conditions (circulation at a standstill)
O
Outcome
Quantity of blood and capacitance (dV/dP) in the arterial and venous systemssurrogate

In live dogs, the venous system demonstrates 18 to 30 times greater capacitance than the arterial system, highlighting its primary role as a blood reservoir.

Cite This Study

Guyton et al. (1956) studied this question.

synapsesocial.com/papers/6a763d4a5db9de976abcb3ffhttps://doi.org/10.1152/ajplegacy.1956.184.2.253
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pressure-volume curves in live, intact dogs1961 · 45 citations
  2. 2Pressure-volume relationships in the pulmonary "venous" system in living dogs.1987 · 9 citations
  3. 3Pressure-Flow Relations in Dog Arteries1966 · 50 citations
  4. 4Dlastolic Pressure-Volume Relationship in the Canine Left Ventricle1971 · 151 citations
  5. 5The Effect of Moderate Changes in Blood Volume on Left and Right Atrial Pressures1956 · 100 citations