Population
H9c2 cardiomyocytes (in vitro model of H2O2-induced necrosis)
Comparison
FGF-2 pretreatment vs H2O2 treatment alone (no FGF-2)
Design
Preclinical
Authors
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FGF-2 protection against H9c2 necrosis is hypothesis-generating; in vivo and clinical studies needed before any therapeutic consideration.
FGF-2 protects cardiomyocytes from oxidative stress-induced necrosis by modulating the PI3K/Akt/FoxO3a/BNIP3L signaling pathway.
Chen et al. (2016) studied this question.
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