Why the study?
Does modulation of CASQ2 protein levels alter cytosolic and SR Ca2+ waves in rat cardiac myocytes?
Does modulation of CASQ2 protein levels alter cytosolic and SR Ca2+ waves in rat cardiac myocytes?
Reduced intra-SR Ca2+ binding activity promotes the generation of Ca2+ waves by accelerating the attainment of threshold free [Ca2+]SR, providing a mechanistic explanation for arrhythmogenesis in CPVT linked to CASQ2 mutations.
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CASQ2 modulation shapes Ca2+ waves in rat myocytes; hypothesis-generating for CPVT mechanisms, pending human validation.
Kubalová et al. (2004) studied this question.
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