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December 4, 2024Scientific ReportsOpen Access

Non-invasive 4D transcranial functional ultrasound and ultrasound localization microscopy for multimodal imaging of neurovascular response

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Authors

RJRebecca M. JonesUniversity of North Carolina at Chapel HillRDRyan M. DeRuiterMayo ClinicHLHanjoo LeeUniversity of North Carolina at Chapel Hill

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Overview

Imaging study demonstrates non-invasive 4D functional ultrasound and localization microscopy of cerebral hemodynamics through the skull, suggesting potential for comprehensive bedside brain...

Key Points

  • To develop a non-invasive, contrast-enhanced transcranial ultrasound platform combining functional ultrasound and localization microscopy to simultaneously image whole-brain microvascular structure and hemodynamics.
  • Integrated 4D functional ultrasound (fUS) and ultrasound localization microscopy (ULM) into a single non-invasive contrast-enhanced transcranial scan.
  • Quantified cerebral blood flow, vessel diameter, velocity, and brain connectivity during baseline and stimulation periods at 30 ms temporal and 14.6 μm spatial resolution.
  • Stimulation induced a statistically significant increase in cerebral blood flow, vessel diameter, and global velocity (all p<0.0001), accompanied by a localized velocity decrease in the activated region.
  • Whole-brain functional connectivity decreased by 24.7% compared to baseline, whereas global flow increased without statistical significance (p=0.11).

Cite This Study

Jones et al. (2024) studied this question.

synapsesocial.com/papers/6a7642bc0d7658322f06da2dhttps://doi.org/10.1038/s41598-024-81243-y
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