Why the study?
It was unknown whether left atrial wall thickness and pulmonary vein dimensions assessed by cardiac CT influence the success rate of first-pass pulmonary vein isolation.
Does left atrial wall thickness and pulmonary vein size influence the acute procedural success of first-pass pulmonary vein isolation in patients with atrial fibrillation?
Does left atrial wall thickness and pulmonary vein size influence the acute procedural success of first-pass pulmonary vein isolation in patients with atrial fibrillation?
Using a standardized contact-force guided ablation protocol (modified CLOSE), first-pass pulmonary vein isolation success is independent of left atrial wall thickness, though wider right superior pulmonary veins may facilitate right-sided isolation.
LAWT by CT need not guide ablation dosing in contact-force PVI; leaves open whether RSPV diameter informs personalized protocols.
Nowadays, a novel contact-force guided ablation technique is used for enclosing pulmonary veins in patients with atrial fibrillation (AF). We sought to determine whether left atrial (LA) wall thickness (LAWT) and pulmonary vein (PV) dimensions, as assessed by cardiac CT, could influence the success rate of first-pass pulmonary vein isolation (PVI). In a single-center, prospective study, we enrolled consecutive patients with symptomatic, drug-refractory AF who underwent initial radiofrequency catheter ablation using a modified CLOSE protocol. Pre-procedural CT was performed in all cases. Additionally, the diameter and area of the PV orifices were obtained. A total of 1034 LAWT measurements and 376 PV area measurements were performed in 94 patients (mean CHA 2 DS 2 -VASc score 2.1 ± 1.5, mean age 62.4 ± 12.6 years, 39.5% female, 38.3% persistent AF). Mean procedure time was 81.2 ± 19.3 min. Complete isolation of all PVs was achieved in 100% of patients. First-pass isolation rate was 76% and 71% for the right-sided PVs and the left-sided PVs, respectively. No difference was found regarding comorbidities and imaging parameters between those with and without first-pass isolation. LAWT (mean of 11 regions or separately) had no effect on the acute procedural outcome on logistic regression analysis (all p ≥ 0.05). Out of all assessed parameters, only RSPV diameter was associated with a higher rate of successful right-sided first pass isolation (OR 1.01, p = 0.04). Left atrial wall thickness does not have an influence on the acute procedural success of PVI using ablation index and a standardized ablation protocol. RSPV diameter could influence the probability of right sided first-pass isolation.
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Boussoussou et al. (2022) studied this question.
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