Overview and Updates on the Role of Genetic Variants in Endometriosis Susceptibility and Pathogenesis

Endometriosis is a complex disorder that leads to inflammation, angiogenesis, oxidative stress, and apoptosis.Studies show that 10-15% of reproductive-aged women are affected by endometriosis.In this review, the etiology, pathophysiology, and the role of genetic factors in endometriosis were discussed.The review focused on the consolidation of the reported genetic factors and their association with endometriosis.Rapid technological advancements in genetics can pave the way for future innovations by providing insight into the exact molecular pathways of pathogenesis, the growth and maintenance of endometriosis, and the discovery of significant insights into a novel treatment target for this unbearably painful illness.