Hypothesizing that the non-aerated lung fraction as evaluated by the quantitative analysis of the lung computed tomography (CT) equals shunt (V A /Q = 0), we used a computational approach to estimate the magnitude of the ventilation–perfusion mismatch in severe COVID-19. The results show that a severe hyperperfusion of poorly ventilated lung region is likely the cause of the hypoxemia observed. The extensive microthrombosis of the pulmonary circulation may represent the pathophysiological mechanism of such V A /Q distribution.
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Busana et al. (2021) studied this question.