Population
STAT1-/- mice and wild type mice infected with murine norovirus (MNV) strains CW3 and CR6
Comparison
Reverse genetics cloning of CW3 and CR6 strains… vs Comparison between CW3 and CR6 strains
Design
Preclinical
Authors
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MNV lethality and persistence determinants in mice should not inform human care; leaves open analogous roles in norovirus pathogenesis.
Specific viral protein domains, including the P domain of the capsid and the N-terminal non-structural protein, are critical determinants of norovirus lethality and persistence in murine models.
David W. Strong (2012) studied this question.
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