What question did this study set out to answer?

To identify the role of the small GTPase Rheb in regulating cell growth and define its position within the Tsc1-Tsc2 and TOR signaling network.

May 23, 2003Nature Cell BiologyOpen Access

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

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Authors

HSHugo StockerUniversity of Zurich TRThomas RadimerskiNovartis (Switzerland)BSBenno SchindelholzCentre for Human Drug Research

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Implication

Genetic and biochemical analysis reveals that Rheb promotes cell growth via S6K downstream of Tsc1-Tsc2 in Drosophila, indicating a key link in TOR-dependent growth control.

Key Points

To identify the role of the small GTPase Rheb in regulating cell growth and define its position within the Tsc1-Tsc2 and TOR signaling network.
Screened and isolated growth-inhibiting loss-of-function Rheb mutants and generated Rheb-overexpressing transgenic Drosophila melanogaster lines.
Performed genetic epistasis and biochemical characterizations to determine pathway interactions between Rheb, the Tsc1-Tsc2 complex, TOR, and S6K.
Rheb loss-of-function mutations caused severe cell growth inhibition, whereas Rheb overexpression autonomously stimulated cell growth.
Genetic epistasis placed Rheb downstream of the Tsc1-Tsc2 tumor suppressor complex within the TOR signaling pathway, identifying ribosomal S6 kinase as a primary downstream effector.

Cite This Study

Stocker et al. (2003) studied this question.

synapsesocial.com/papers/6a764569d7f18fdd73b1b86a https://doi.org/10.1038/ncb995

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Implication

Genetic and biochemical analysis reveals that Rheb promotes cell growth via S6K downstream of Tsc1-Tsc2 in Drosophila, indicating a key link in TOR-dependent growth control.

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

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Member takes

Implication

Key Points

Cite This Study

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

Discussion

Member takes

Implication

Key Points

Cite This Study

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