Biocide mixture (CMIT/MIT) induces neurotoxicity through the upregulation of the MAPKs signaling pathways

5-Chloro-2-methyl-2h-isothiazolin-3-one and 2-methyl-2h-isothiazolin-3-one (CMIT/MIT) are widely used, but they may be harmful to the skin and lungs. CMIT/MIT reduces cell viability and induces lactate dehydrogenase (LDH) release in SHSY5Y cell line. CMIT/MIT induces oxidative stress, lipid peroxidation, and activates endogenous antioxidant system. CMIT/MIT induces proinflammatory cytokines release. CMIT/MIT promoted the upregulation of MAPKs and induces apoptosis.