Why the study?
Does the single-pill combination of aliskiren, amlodipine, and hydrochlorothiazide improve blood pressure reduction in patients with hypertension requiring three drugs for adequate control?
Does the single-pill combination of aliskiren, amlodipine, and hydrochlorothiazide improve blood pressure reduction in patients with hypertension requiring three drugs for adequate control?
The single-pill combination of aliskiren, amlodipine, and hydrochlorothiazide is a reasonable and effective choice for hypertensive patients requiring triple therapy.
High blood pressure is the leading risk factor for death and disability worldwide, and the prevalence is increasing. Effective treatment decreases the risk of adverse events in proportion to blood pressure reduction. Combination antihypertensive therapy reduces blood pressure promptly and effectively. Single-pill combinations reduce the pill burden and improve adherence, efficacy, and tolerability of treatment compared with single drug pills. A significant portion of the hypertensive population will require three drugs for adequate control. The single-pill combination of aliskiren, amlodipine, and hydrochlorothiazide is based on complementary mechanisms of action. Clinical trials have shown it to be a safe and effective treatment for hypertension. This combination is a reasonable choice in clinical practice for patients with hypertension that requires three drugs for effective treatment.
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Jaimes et al. (2013) studied this question.
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