The uptake of catechol amines at high perfusion concentrations in the rat isolated heart: a novel catechol amine uptake process

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Population

Rat isolated heart

Comparison

Perfusion with high concentrations of adrenaline… vs Perfusion with lower concentrations

Design

Preclinical

Authors

Discussion

Hypothesis-generating for dual cardiac catecholamine uptake; leaves open human translation and therapeutic relevance.

Population

Rat isolated heart

Intervention

Perfusion with high concentrations of adrenaline and noradrenaline (e.g., (±)-adrenaline at 5.0 μg/ml)

Comparator

Perfusion with lower concentrations (e.g., noradrenaline ~0.2 μg/ml or adrenaline ~0.5 μg/ml)

Outcome

Uptake of catecholaminessurrogate

Identifies a novel, distinct mechanism for catecholamine uptake in the heart at high concentrations.

Leslie L. Iversen (1997) studied this question.

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