Why the study?
Both augmented inflammatory reaction and low vitamin D status are associated with depression, but the magnitude of their relationships is unclear.
Does cholecalciferol supplementation improve depression severity and pro-inflammatory biomarkers in patients with mild to moderate depression?
Population
56 patients aged 18-60 years with mild to moderate depression
Comparison
50,000 IU cholecalciferol every 2 weeks vs placebo
Design
Double-blind randomized clinical trial
Follow-up
8 weeks
Authors
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Supports adjunctive vitamin D for mild-moderate depression symptom relief; leaves open effects on inflammatory pathways.
Does cholecalciferol supplementation improve depression severity and pro-inflammatory biomarkers in patients with mild to moderate depression?
High-dose vitamin D supplementation significantly improved depression severity in patients with mild to moderate depression, though it did not alter systemic pro-inflammatory biomarker concentrations.
Kaviani et al. (2022) studied this question.
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