Why the study?
Adipokines exert potent modulatory actions and have complex roles in obesity, metabolic syndrome, and immune-mediated diseases, but their specific effects require exploration.
Adipokines are key mediators in the pathogenesis of various autoimmune and inflammatory diseases, presenting potential future targets for pharmacological treatment.
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Adipokines may link obesity to immune dysregulation; leaves open targeted therapies pending mechanistic trials.
White adipose tissue has emerged as a highly dynamic organ that releases a plethora of immune and inflammatory mediators that are involved in obesity, metabolic syndrome and immune mediated diseases. Adipokines have complex role in various physiological and pathological processes by exerting potent modulatory actions on target tissues In this Review, In this review, we explore the effects of different adipokines, focusing primarily on leptin, adiponectin, visfatin and resistin in causing immune-mediated and/or inflammatory diseases.
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Kharbanda et al. (2020) studied this question.
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