Population
Rats with experimental hypertension induced by aortic coarctation
Design
Preclinical
Follow-up
72 hours and 9 days
Authors
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Hypothesis-generating for pressure-overload hypertrophy mechanisms; leaves open translation to human disease or therapy.
Early increases in inositol lipid hydrolysis and proto-oncogene expression are key cellular signals in the development of pressure-induced cardiovascular hypertrophy.
Maclver et al. (2008) studied this question.